Functional biases in GRB's spectral parameter correlations

Gamma Ray Bursts (GRBs) show evidence of different spectral shapes, light curves, duration, host galaxies and they explode within a wide redshift range. However, the most of them seems to follow very tight correlations among some observed quantities relating to their energetic. If true, these correlations have significant implications on burst physics, giving constraints on theoretical models. Moreover, several suggestions have been made to use these correlations in order to calibrate GRBs as standard candles and to constrain the cosmological parameters. We investigate the cosmological relation between low energy $\alpha$ index in GRBs prompt spectra and the redshift $z$. We present a statistical analysis of the relation between the total isotropic energy $E_{iso}$ and the peak energy $E_p$ (also known as Amati relation) in GRBs spectra searching for possible functional biases. Possible implications on the $E_{iso}$ vs $E_p$ relation of the $\alpha$ vs $(1+z)$ correlation are evaluated. We used MonteCarlo simulations and the boostrap method to evaluate how large are the effects of functional biases on the $E_{iso}$ vs $E_p$. We show that high values of the linear correlation coefficent, up to about 0.8, in the $E_{iso}$ vs $E_p$ relation are obtained for random generated samples of GRBs, confirming the relevance of functional biases. Astrophysical consequences from $E_{iso}$ vs $E_p$ relation are then to be revised after a more accurate and possibly bias free analysis.Comment: 6 pages, 6 figures, conference poster session: "070228: The Next Decade of Gamma-Ray Burst Afterglows", Amsterdam, March 2007, MNRAS submitte

Optimal control of motorsport differentials

Modern motorsport limited slip differentials (LSD) have evolved to become highly adjustable, allowing the torque bias that they generate to be tuned in the corner entry, apex and corner exit phases of typical on-track manoeuvres. The task of finding the optimal torque bias profile under such varied vehicle conditions is complex. This paper presents a nonlinear optimal control method which is used to find the minimum time optimal torque bias profile through a lane change manoeuvre. The results are compared to traditional open and fully locked differential strategies, in addition to considering related vehicle stability and agility metrics. An investigation into how the optimal torque bias profile changes with reduced track-tyre friction is also included in the analysis. The optimal LSD profile was shown to give a performance gain over its locked differential counterpart in key areas of the manoeuvre where a quick direction change is required. The methodology proposed can be used to find both optimal passive LSD characteristics and as the basis of a semi-active LSD control algorithm

COPD phenotypes and machine learning cluster analysis : A systematic review and future research agenda

Funding This research did not receive any specific grant from funding agencies in the public, commercial, or ot-for-profit sectors.Peer reviewedPostprin

Fast Decliner Phenotype of Chronic Obstructive Pulmonary Disease (COPD) : Applying Machine Learning for Predicting Lung Function Loss

Acknowledgements We acknowledge patients for allowing their data to be used for surveillance and research. Practices who have agreed to be part of the RCGP RSC and allow us to extract and used health data for surveillance and research. Ms. Filipa Ferreira from RCGP and Mr. Julian Sherlock from the University of Surrey. Apollo Medical Systems for data extraction. Collaboration with EMIS, TPP, In-Practice and Micro-test CMR supplier for facilitating data extraction. Colleagues at Public Health England. Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectorsPeer reviewedPublisher PD

Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study

BACKGROUND: Family studies and heritability estimates provide evidence for a genetic contribution to variation in the human life span. METHODS:We conducted a genome wide association study (Affymetrix 100K SNP GeneChip) for longevity-related traits in a community-based sample. We report on 5 longevity and aging traits in up to 1345 Framingham Study participants from 330 families. Multivariable-adjusted residuals were computed using appropriate models (Cox proportional hazards, logistic, or linear regression) and the residuals from these models were used to test for association with qualifying SNPs (70, 987 autosomal SNPs with genotypic call rate [greater than or equal to]80%, minor allele frequency [greater than or equal to]10%, Hardy-Weinberg test p [greater than or equal to] 0.001).RESULTS:In family-based association test (FBAT) models, 8 SNPs in two regions approximately 500 kb apart on chromosome 1 (physical positions 73,091,610 and 73, 527,652) were associated with age at death (p-value < 10-5). The two sets of SNPs were in high linkage disequilibrium (minimum r2 = 0.58). The top 30 SNPs for generalized estimating equation (GEE) tests of association with age at death included rs10507486 (p = 0.0001) and rs4943794 (p = 0.0002), SNPs intronic to FOXO1A, a gene implicated in lifespan extension in animal models. FBAT models identified 7 SNPs and GEE models identified 9 SNPs associated with both age at death and morbidity-free survival at age 65 including rs2374983 near PON1. In the analysis of selected candidate genes, SNP associations (FBAT or GEE p-value < 0.01) were identified for age at death in or near the following genes: FOXO1A, GAPDH, KL, LEPR, PON1, PSEN1, SOD2, and WRN. Top ranked SNP associations in the GEE model for age at natural menopause included rs6910534 (p = 0.00003) near FOXO3a and rs3751591 (p = 0.00006) in CYP19A1. Results of all longevity phenotype-genotype associations for all autosomal SNPs are web posted at http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?id=phs000007. CONCLUSION: Longevity and aging traits are associated with SNPs on the Affymetrix 100K GeneChip. None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging

Blazar Optical Variability in the Palomar-QUEST Survey

We study the ensemble optical variability of 276 FSRQs and 86 BL Lacs in the Palomar-QUEST Survey with the goal of searching for common fluctuation properties, examining the range of behavior across the sample, and characterizing the appearance of blazars in such a survey so that future work can more easily identify such objects. The survey, which covers 15,000 square degrees multiple times over 3.5 years, allows for the first ensemble blazar study of this scale. Variability amplitude distributions are shown for the FSRQ and BL Lac samples for numerous time lags, and also studied through structure function analyses. Individual blazars show a wide range of variability amplitudes, timescales, and duty cycles. Of the best sampled objects, 35% are seen to vary by more than 0.4 magnitudes; for these, the fraction of measurements contributing to the high amplitude variability ranges constantly from about 5% to 80%. Blazar variability has some similarities to that of type I quasars but includes larger amplitude fluctuations on all timescales. FSRQ variability amplitudes are particularly similar to those of QSOs on timescales of several months, suggesting significant contributions from the accretion disk to the variable flux at these timescales. Optical variability amplitudes are correlated with the maximum apparent velocities of the radio jet for the subset of FSRQs with MOJAVE VLBA measurements, implying that the optically variable flux's strength is typically related to that of the radio emission. We also study CRATES radio-selected FSRQ candidates, which show similar variability characteristics to known FSRQs; this suggests a high purity for the CRATES sample.Comment: 29 pages, 12 figures. Accepted for publication in Ap